Structure of macrophage migration inhibitory factor from human lymphocytes
نویسندگان
چکیده
منابع مشابه
Oxygen regulation of macrophage migration inhibitory factor in human placenta.
Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine involved in regulation of macrophage function. In addition, MIF may also play a role in murine and human reproduction. Although both first trimester trophoblast and decidua express MIF, the regulation and functional significance of this cytokine during human placental development remains unclear. We assessed M...
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The ability of hydrocortisone to modify antigen-mediated inhibition of macrophage migration, an in vitro correlate of cellular immunity in the guinea pig, was investigated. Only the glucocorticoids, hydrocortisone and dexamethasone, significantly blocked migration inhibitory factor (MIF) activity in pharmacologic concentrations. Hydrocortisone had no effect on antigen "processing" by macrophage...
متن کاملHuman macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory mediator with the ability to induce various immunomodulatory responses and override glucocorticoid-driven immunosuppression. Some of these functions have been linked to the unusual enzymatic properties of the protein, namely tautomerase and oxidoreductase activities. However, there are conflicting reports regarding the functiona...
متن کاملHuman Macrophage Migration Inhibitory Factor (mif): a Proven Immunomodulatory Cytokine?
HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF): A PROVEN IMMUNOMODULATORY CYTOKINE? Alex Kudrin‡, Martin Scott§, Steven Martin§, Chun-wa Chung§, Rachelle Donn¶¥, Andrew McMaster¥, Stuart Ellison¥, David Ray¶, Keith Ray‡, Michael Binks‡ From the ‡Department of Disease Biology, Rheumatology and Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, SG1 2NY. §Discovery Research, GlaxoSmithK...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1996
ISSN: 0108-7673
DOI: 10.1107/s0108767396092483